Galanthamine hydrobromide (Galantamine hydrobromide, Galanthamine HBr),又称氢溴酸加兰他敏、氢溴酸加兰它敏或氢溴酸加兰他敏,是竞争性的乙酰胆碱酯酶AChE选择性抑制剂,IC50为0.35 μM,临床上用于用于治疗逆转神经肌肉阻滞、重症肌无力和幼儿脑型麻痹症。
参考文献
[1] H Ogura, et al. Comparison of inhibitory activities of donepezil and other cholinesterase inhibitors on acetylcholinesterase and butyrylcholinesterase in vitro. Methods Find Exp Clin Pharmacol. 2000 Oct;22(8):609-13.
[2] Storch A, et al. Physostigmine, galanthamine and codeine act as 'noncompetitive nicotinic receptor agonists' on clonal rat pheochromocytoma cells. Eur J Pharmacol. 1995 Aug 15;290(3):207-19.
[3] Balpreet Matharu, et al. Galantamine inhibits beta-amyloid aggregation and cytotoxicity. J Neurol Sci. 2009 May 15;280(1-2):49-58.
[4] Van Dam D, et al. Symptomatic effect of donepezil, rivastigmine, galantamine and memantine on cognitive deficits in the APP23 model. Psychopharmacology (Berl). 2005 Jun;180(1):177-90.
冰袋运输。粉末直接保存于-25~-15℃,有效期3年。建议溶解分装后于-25~-15℃干燥保存,避免反复冻融。





