RITA (NSC 652287, NSC652287)是p53-HDM-2相互作用抑制剂，抑制p53泛素化，诱导DNA-蛋白质和DNA-DNA交联，作用于多种癌细胞表现出不同的细胞毒性，具有潜在的抗癌活性。

参考文献

1.Issaeva N, et al. Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors. Nat Med. 2004 Dec;10(12):1321-8.

2.Nieves-Neira W, et al. DNA protein cross-links produced by NSC 652287, a novel thiophene derivative active against human renal cancer cells. Mol Pharmacol. 1999 Sep;56(3):478-84.

3.Zhao CY, et al. Rescue of p53 function by small-molecule RITA in cervical carcinoma by blocking E6-mediated degradation. Cancer Res. 2010 Apr 15;70(8):3372-81.

冰袋运输。粉末直接保存于-20℃，有效期3年。建议分装后-20℃干燥保存，避免反复冻融。