(R)-(-)-Gossypol acetic acid (AT-101 (acetic acid); (-)-Gossypol acetic acid; (R)-Gossypol acetic acid)，又称(R)-(-)-醋酸棉酚，是醋酸棉酚的R-(-)对映体，能结合到Bcl-2、Mcl-1和Bcl-xL蛋白，诱导细胞凋亡，具有潜在抗癌活性。

参考文献

1.Wang G, et al. Structure-based design of potent small-molecule inhibitors of anti-apoptotic Bcl-2 proteins. J Med Chem. 2006 Oct 19;49(21):6139-42.

2.Paoluzzi L, et al. Targeting Bcl-2 family members with the BH3 mimetic AT-101 markedly enhances the therapeutic effects of chemotherapeutic agents in in vitro and in vivo models of B-cell lymphoma. Blood. 2008 Jun 1;111(11):5350-8.

3.Balakrishnan K, et al. AT-101 induces apoptosis in CLL B cells and overcomes stromal cell-mediated Mcl-1 induction and drug resistance. Blood. 2009 Jan 1;113(1):149-53.

4.Zerp SF, et al. AT-101, a small molecule inhibitor of anti-apoptotic Bcl-2 family members, activates the SAPK/JNK pathway and enhances radiation-induced apoptosis. Radiat Oncol. 2009 Oct 23;4:47.

冰袋运输。粉末直接保存于-20℃，有效期3年。建议分装后-20℃干燥保存，避免反复冻融。