Plerixafor octahydrochloride (AMD3100 octahydrochloride, JM3100 octahydrochloride, SID791 octahydrochloride, JM 3100 8HCl, Plerixafor 8HCl, AMD3100 8HCl)，又称盐酸普乐沙福或普乐沙福盐酸盐，是一种CXCR4选择性拮抗剂，作用于CXCR4和CXCL12介导的趋化作用，IC₅₀分别为44 nM和5.7 nM，还可以抑制CXCR4介导的HIV感染。Plerixafor也是一种免疫刺激剂，用于体内造血干细胞动员。

参考文献

1.Zabel BA, et al. Elucidation of CXCR7-mediated signaling events and inhibition of CXCR4-mediated tumor cell transendothelial migration by CXCR7 ligands. J Immunol. 2009 Sep 1;183(5):3204-11.

2.Mercurio L, et al. Targeting CXCR4 by a selective peptide antagonist modulates tumor microenvironment and microglia reactivity in a human glioblastoma model. J Exp Clin Cancer Res. 2016 Mar 25;35:55.

3.Yang J, et al. Continuous AMD3100 Treatment Worsens Renal Fibrosis through Regulation of Bone Marrow Derived Pro-Angiogenic Cells Homing and T-Cell-Related Inflammation. PLoS One. 2016 Feb 22;11(2):e0149926.

4.Chu PY, et al. CXCR4 Antagonism Attenuates the Development of Diabetic Cardiac Fibrosis. PLoS One. 2015 Jul 27;10(7):e0133616.

5.Schols D, et al. HIV co-receptor inhibitors as novel class of anti-HIV drugs. Antiviral Res. 2006 Sep;71(2-3):216-26.

冰袋运输。粉末直接保存于-20℃，有效期3年。建议分装后-20℃干燥保存，避免反复冻融。