Phorbol 12,13-dibutyrate (Phorbol dibutyrate; PDBu)是一种高效的PKC激活剂，抑制OK细胞中Na⁺/ K⁺ ATPase的转运活性。PKC在调节多种细胞过程如胞吐作用、基因表达、细胞增殖和分化以及肿瘤促进中起重要作用，Phorbol 12,13-dibutyrate能够在PKC的刺激中取代内源性激活剂DAG，并参与肿瘤形成和进展的多阶段过程。

参考文献

[1] Middleton JP, et al. Heterogeneity of protein kinase C-mediated rapid regulation of Na/K-ATPase in kidney epithelial cells. J Biol Chem. 1993 Jul 25;268(21):15958-64.

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冰袋运输。粉末直接保存于-20℃，有效期3年。建议分装后-20℃干燥保存，避免反复冻融。