Scutellarin(又名Breviscapine; Breviscapin; Scutellarein-7-glucuronide; Breviscapinu; 野黄芩苷;野黄芩甙;黄芩素苷;灯盏花乙素;灯盏乙素;黄芩苷;印黄芩苷)是从黄芩中分离出的一种活性黄酮,可抑制破骨细胞中RANKL介导的MAPK和NF-κB信号通路,并下调HCC细胞中的STAT3/Girdin/Akt信号通路。Scutellarin具有抗HIV-1IIIB,HIV-1(74V)和HIV-1KM018的活性,IC50分别为26 μM,253 μM和136 μM。Scutellarin可用来抗炎、抗氧化应激,治疗心脑血管、肿瘤、青光眼、肾肝等疾病。
参考文献
[1] Feng, Zhang, Tu, et al. Novel function of scutellarin in inhibiting cell proliferation and inducing cell apoptosis of human Burkitt lymphoma Namalwa cells. 2012, 53(12):2456-2464.
[2] Haitao Xu, Songyan Zhang. Scutellarin‐Induced Apoptosis in HepG2 Hepatocellular Carcinoma Cells Via a STAT3 Pathway. 2013, 27(10):1524-1528.
[3] Yang Ning, et al. Scutellarin suppresses growth and causes apoptosis of human colorectal cancer cells by regulating the p53 pathway. 2017, 15(2):929-935.
[4] Haixia Li, et al. Potentiation of scutellarin on human tongue carcinoma xenograft by low-intensity ultrasound. 2018, 8(3).
[5] Li H X, et al. Scutellarin inhibits the growth and invasion of human tongue squamous carcinoma through the inhibition of matrix metalloproteinase-2 and -9 and αvβ6 integrin[J].Int J Oncol, 2013,42 (5): 1674-81.
冰袋运输。粉末直接保存于-25~-15℃,有效期2年。建议避光干燥保存,避免反复冻融。