Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity). Critical for early embryogenesis and for embryonic stem cell pluripotency. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity).

推荐稀释比 WB:1/500-1/1000;IHC:1/100-1/200;IF:1/50-1/200

Western blot analysis of SOX2 in (1) NCCIT lysates; (2) F9 lysates using SOX2 antibody.

Immunohistochemistry analysis of paraffin-embedded human cervix carcinoma using SOX2 antibody. High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.

Immunofluorescence analysis of SOX2 in NCCIT cells using SOX2 antibody(green),and DAPI(blue).

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.