This gene encodes a highly abundant bone protein secreted by osteoblasts that regulates bone remodeling and energy metabolism. The encoded protein contains a Gla (gamma carboxyglutamate) domain, which functions in binding to calcium and hydroxyapatite, the mineral component of bone. Serum osteocalcin levels may be negatively correlated with metabolic syndrome. Read-through transcription exists between this gene and the neighboring upstream gene, PMF1 (polyamine-modulated factor 1), but the encoded protein only shows sequence identity with the upstream gene product.

推荐稀释比 WB:1/500-1/1000;IHC:1/50-1/100

Western blot analysis of Osteocalcin in MG63 whole lysates using Osteocalcin antibody.

Immunohistochemistry analysis of paraffin-embedded Human tonsils using Osteocalcin antibody, with DAB staining.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.

Western blot analysis of Osteocalcin in MG63 whole lysates using Osteocalcin antibody.

Western blot analysis of Osteocalcin in MG63 whole lysates using Osteocalcin antibody

Western blot analysis of Osteocalcin (arrow) in 293 lysates using Osteocalcin antibody (Nterm).293 cell either nontransfected (Lane 1) or transiently transfected with the BGLAP gene (Lane 2).

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