Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. Lamin A and C are present in equal amounts in the lamina of mammals. Play an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics. Prelamin-A/C can accelerate smooth muscle cell senescence. It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence.

Western

Western blot analysis of Lamin A/C in rat heart, rat skeletal muscle lysates using Lamin A/C antibody.

Western

Western blot analysis of Lamin A/C in 3T3, Hela lysates using Lamin A/C antibody.

Immunocytochemistry

Immunocytochemistry analysis of Lamin A/C(green) in Hela using Lamin A/C antibody,and DAPI(blue)

Immunohistochemistry

Immunohistochemistry analysis of paraffin-embedded Human breast cancer using Lamin A/C antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.