This gene encodes a member of the nectin family. The encoded protein contains two immunoglobulin-like (Ig-like) C2-type domains and one Ig-like V-type domain. It is involved in cell adhesion through trans-homophilic and -heterophilic interactions. It is a single-pass type I membrane protein. The soluble form is produced by proteolytic cleavage at the cell surface by the metalloproteinase ADAM17/TACE. The secreted form is found in both breast tumor cell lines and breast tumor patients. Mutations in this gene are the cause of ectodermal dysplasia-syndactyly syndrome type 1, an autosomal recessive disorder. Alternatively spliced transcript variants have been found but the full-length nature of the variant has not been determined.

Purity:SDS-PAGE

Anti-Nectin-4 Reference Antibody (enfortumab) on SDS-PAGE under reducing (R) condition. The purity of the protein is greater than 95%.

Purity:SEC-HPLC

The purity of Anti-Nectin-4 Reference Antibody (enfortumab) is 100%, determined by SEC-HPLC.

Bioactivity:ELISA

Immobilized human NECTIN 4 His at 2 ug/mL can bind Anti-Nectin-4 Reference Antibody (enfortumab), EC50=0.003846 ug/mL.

-25~-15℃保存，有效期1年。