Brefeldin A，简称BFA，一种常用的可逆性蛋白转运抑制剂，是一种真菌代谢产物，可破坏高尔基体的结构并抑制其功能，进而特异地阻断蛋白质从内质网(ER)向高尔基体(Golgi)的转运。BFA 可抑制coat proteins（如β-COP and ADP-ribosylation factor (ARF)）与高尔基体的结合并抑制GDP-GTP交换。
Brefeldin A也常被用于抑制细胞因子等蛋白的分泌，并用于增强分泌蛋白的免疫染色检测。Brefeldin A可激活神经鞘磷脂循环(sphingomyelin cycle)，还可诱导一些肿瘤细胞发生凋亡。
本品为溶于DMSO的BFA储存液，浓度为5 mg/mL，推荐使用浓度范围是1-50 μM，具体的最佳工作浓度请参考相关文献，并根据实验目的以及所用特定细胞和组织，进行优化。
| 英文别名 (English Synonym) | γ,4-Dihydroxy-2-[6-hydroxy-1-heptenyl]-4-cyclopentanecrotonic acid λ-lactone; cyanein; BFA；Decumbin |
| 中文名称 (Chinese Name) | 布雷非德菌素A |
| 通路 (Pathway) | Autophagy--Autophagy |
| CAS号 (CAS NO.) | 20350-15-6 |
| 分子式 (Formula) | C16H24O4 |
| 分子量 (Molecular Weight) | 280.36 |
| 纯度 (Purity) | ≥99% |
| 溶解性 (Solubility) | 溶于DMSO (100 mg/mL) |
| 结构式 (Structure) |
冰袋运输。溶液在-80℃稳定保存2年，-20℃稳定保存1年，4℃稳定保存6个月。
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